Question #1: Describe Wallach’s Law:
ANSWER: The interlinking of C5H8 isoprene units to form terpenes


Question #2: The majority of early terpene scientists were mostly chemists from which country:

a. Romania
b. United Kingdom
c. Switzerland
d. Germany
e. Russia

Question #3: Draw a line to connect each terpene with the proper category:

a. Farnesene e. Acyclic monoterpene
b. Beta-caryophyllene f. Acyclic sesquiterpene
c. Pinene g. Bicyclic monoterpene
d. Linalool h. Bicyclic sesquiterpene

Question #4: Which scientist discovered the THC molecule?
ANSWER: A – Raphael Mechoulam

a. Raphael Mechoulam
b. Susan Trapp
c. Wilhelm Triebs
d. Ethan Russo

Question #5: Which researcher is noted for their studies on the interactions and putative synergy between THC and CBD?
ANSWER: D – Ethan Russo

a. Raphael Mechoulam
b. Susan Trapp
c. Wilhelm Triebs
d. Ethan Russo

Question #6: What is the top monoterpene in cannabis?
ANSWER: Pinene


Question #7: What is the top sesquiterpene in cannabis?
ANSWER: Beta-caryophyllene

Question #8: What is the most common flavonoid in cannabis?
ANSWER: Cannflavin A


Question #9: Flavonoids are based on which molecular skeleton:

a. C4C2C4
b. C6C3C6
c. C2C4C2
d. C3C6C3

Question #10: Flavonoids are named after the Latin word, ‘flavus.’ What does this word mean?
ANSWER: E – Yellow

a. Of flavor, flavorful
b. To season, as in food
c. Purple
d. “favored one”
e. Yellow
f. Herbaceous

Question #11: Some terpenes and flavonoids can influence the growth cycles of other plants and some insects. Terpenes and flavonoids used by plants for this purpose are called:
ANSWER: A – Allelochemicals

a. Allelochemicals
b. Phytochemicals
c. Phytonutrients
d. Alleyoopicals
e. Oilvetols
f. Geranyls

Question #12: Pinene and myrcene are found in high concentrations in which trees?
ANSWER: B – Coniferous trees

a. Deciduous trees
b. Coniferous trees
c. Ficus trees
d. Synthetic trees
e. Sigillaria trees

Question #13: The basic flavonoid molecule contains how many rings?

a. 4
b. 3
c. 2
d. 5

Question #14: This cannabinoid is both an endocannabinoid and a phytocannabinoid:
ANSWER: C – Anandamide

a. Delta-11-tetrahydrocannabinol
b. Delta-8-tetrahydrocannabinol
c. Anandamide
d. Beta-caryophyllene
e. Fenchol alcohol

Question #15: Explain the “oid” distinction in terpenes, cannabinoids, and flavonoids:
ANSWER: Occurrence of an oxygen atom in the molecule; compound is oxygenated


Question #16: Explain the “A” designation of THCA, CBDA, CBCA, CBGA:
ANSWER: The “A” denotes the acid version of the compound before decarboxylation


Question #17: Define this acronym: CB1
ANSWER: Cannabinoid Receptor type 1


Question #18: Name the Top 10 terpenes in cannabis:
ANSWER: Pinene, Beta-Caryophyllene, Myrcene, Limonene, Humulene, Linalool, Bisabolol, Nerolidol, Ocimene, Terpinolene


Question #19: Name the Top 5 flavonoids in cannabis:
ANSWER: Cannflavin A, Cannflavin B, Orientin, Rutin, Apigenin


Question #20: To retain the most monoterpenes possible, when is the best time to harvest cannabis?
ANSWER: Early morning, before the sun comes up and / or temperatures rise


Question #21: Which of the following is a Top 10 terpene in cannabis:
ANSWER: B – Terpinolene

a. Terpineol
b. Terpinolene
c. Terpinene
d. Turpentine

Question #22: Which Top 10 terpene is named after the hops plant?
ANSWER: D – Humulene

a. Valencene
b. Terpinolene
c. Myrcene
d. Humulene
e. Humulus

Question #23: Which terpene is the primary constituent responsible for the smell of roses?
ANSWER: D – Geraniol

a. Geranyl acetate
b. Guaiol
c. Bergamotene
d. Geraniol

Question #24: Which bicyclic sesquiterpene is responsible for the spicy characteristics of black pepper?
ANSWER: A – Beta-caryophyllene

a. Beta-caryophyllene
b. Caryophyllene oxide
c. 4-ol-caryophyllene
d. 2,-8-caryophyllene

Question #25: What is the primary factor determining the terpene, flavonoid, and cannabinoid profile of a cannabis chemovar?
ANSWER: B – Genetics

a. Number of rings
b. Genetics
c. Oxygenated state
d. Indica / sativa

Question #26: Beta-sitosterol, often included in cannabis flavonoid tests, is not a flavonoid. Instead, this compound is a:
ANSWER: C – Phytosterol

a. Plant cortisone
b. Steroidal acid
c. Phytosterol
d. Phytol

Question #27: Name 3 experimental methods of manipulating the terpene profile of a cannabis strain / chemovar:
ANSWER: Genetics, harvest timing, disease stress, insect stress, co-planting for allelochemical stress, mechanical wounding, chemical treatment

______________________, ______________________, ______________________

Question #28: D-limonene and L-limonene, as well as D8-THC and D9-THC are examples of:
ANSWER: D – Isomers

a. Stereometrics
b. Functional groups
c. Geranyl substitutions
d. Isomers

Question #29: Myrcene is a well-known:
ANSWER: A – Sedative

a. Sedative
b. Diuretic
c. Antispasmodic
d. Analgesic

Question #30: Commercially-produced limonene is sourced primarily from:
ANSWER: B – Oranges

a. Lemons
b. Oranges
c. Limes
d. Grapefruit

Question #31: Which scientists first proposed the “Entourage Effect?”
ANSWER: C – Ben-Shabat and Mechoulam, et. al.

a. Russo and McPartland, et. al.
b. Pickens and Fairbanks
c. Ben-Shabat and Maechoulam, et. al.
d. Cogan and Duggan, et. al.

Question #32: Most research into the entourage effect or synergy has focused on which two compounds?

a. THC and CBG
b. CBGA and THC
c. THC and CBC
d. CBC and THC

Question #33: Which compound is the precursor to most of the cannabinoids?


Question #34: Name one of Russo’s 3 papers that are heavily cited as evidence of synergy:
ANSWER: A Tale of two Cannabinoids, Taming THC, The Case for the Entourage Effect


Question #35: The Entourage Effect takes place in:
ANSWER: D – Endocannabinoid System

a. Geranyl phosphate pathway
b. Limbic system
c. Mevalonate pathway
d. Endocannabinoid system